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In the following part, we will describe the different vaccine-based strategies of senotherapeutics that have been studied, and we will show the limitations of some of them to be used into clinics

However, these inferences are often derived from predictive functional analyses based on 16S rRNA sequencing rather than direct metabolomic measurements, and direct clinical validation in GLP-1 RA-treated cohorts remains limited ( Preclinical studies provide mechanistic evidence for interactions between the gut microbiota and incretin biology, which could suggest potential relevance to GLP-1 RA response

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But some symptoms warrant immediate attention